Alzheimer's disease: Dual mechanism of actions of overactive and cytosolic BRCA1 in neuronal death

February 7th, 2018 | Posted by admin in Uncategorized

A new study suggests an association between overactive and cytosolic BRCA1, the major guardian of genomic stability, and neurons death in Alzheimer's disease (AD). Upregulated BRCA1 is associated with both aberrant DNA damage response (DDR) and dysfunction of presenilin 1 (PS1). The findings support the hypothesis that genotoxic stress manifested among others by activation of DDR and destabilization of cell cycle checkpoints cause neuronal death in Alzheimer's disease.
Source: Care Giving Science Daily

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